Proximal calciphylaxis treated with calcimimetic 'Cinacalcet'.
نویسندگان
چکیده
Calciphylaxis is a rare condition affecting patients suffering from end-stage renal failure, characterised by cutaneous ischaemia and necrosis. The management of calciphylaxis is challenging owing to the lack of optimal medical therapy, although parathyroidectomy has shown some benefit. We present a case of severe proximal calciphylaxis treated with a small dose of the calcimimetic 'Cinacalcet'.
منابع مشابه
Cinacalcet for the treatment of calciphylaxis.
Calciphylaxis is characterized by cutaneous ischemia and necrosis and is associated with a very high mortality rate. It usually affects patients who are undergoing dialysis or who have received a kidney transplant. There is no optimal treatment, but parathyroidectomy has shown some benefit. We report herein a case of a patient with calciphylaxis and secondary hyperparathyroidism who was success...
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recently been drawn to the possible interest of einacalcet. a calcimimetic drug that increases the sensitivity of PTH-secreting cells to extracellular calcium, resulting in a decrease of PTH production. This molecule is currently routinely used in end-stage renal failureassociated secondary hyperparathyroidism (4) and its efficiency in calciphylaxis has already been reported in two patients, in...
متن کاملUse of sodium thiosulphate in a multi-interventional setting for the treatment of calciphylaxis in dialysis patients.
BACKGROUND Calciphylaxis is a life-threatening complication in patients with end-stage renal disease (ESRD). No established therapy exists so far. The aim of the present study was to determine the therapeutic response to a multi-interventional treatment regimen with consistent use of sodium thiosulphate (STS) in an Austrian cohort of calciphylaxis patients. METHODS We retrospectively collecte...
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DESCRIPTION A 17 year old presentedwith a painful, erythematous lesion to the dorsum of his right foot followingminor trauma. The lesion was cold, 5 cm in diameter with a well-defined edge surrounding scattered petechiae (figure 1). He was unable to move his foot or weight bear due to pain. C-reactive protein and plain x-rays were normal. The patient has chronic kidney disease (CKD) stage 5 due...
متن کاملRegression of vascular calcification following an acute episode of calciphylaxis: a case report
INTRODUCTION In clinical situations, vascular calcification tends to progress and is difficult to completely arrest or reverse. Calciphylaxis, a severe complication of end-stage renal disease, is a specific form of vascular calcification. Control studies have provided evidence that monotherapy with sodium thiosulfate or cinacalcet delays the progression of vascular calcification. Successful tre...
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عنوان ژورنال:
- Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
دوره 23 1 شماره
صفحات -
تاریخ انتشار 2008